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KMID : 0363420050190010153
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Journal of Korean Oriental Pediatrics
2005 Volume.19 No. 1 p.153 ~ p.171
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Effect of Gamisogunjung-tang on Antioxidation Activity in Rats Induced Aging by D-Galactose
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Park Sun-Young
Baek Jung-Han
Seo Jeong-Min
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Abstract
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Objective: This experiment has been done to evaluate the effects of Gamisogunjung-tang(GST) on antioxidant capability and lipidic concentration in blood which are presumed to be related to aging.
Method: In this study, we divided 14 weeks old SD rats into normal group, control group and GST group. Control and GST group were induced aging by D-galactose. At the same time GST group were administered extract of Gamisogunjung-tang for 6 weeks. After then we took blood, and measured the activities of SOD, GSH-px, catalase in erythrocytes and measured TBARS values, concentrations of total lipid, tryglyceride, total cholesterol, HDL-cholesterol in plasma.
Results: The activities of SOD, GSH-px, catalase in erythrocytes increased significantly in GST group compared with control group. The value of TBARS and the concentration of total lipid, total cholesterol in plasma decreased significantly in GST group compared with control group. The concentration of HDL-cholesterol increased significantly in GST group compared with control group. The concentration of triglyceride were not noticeable.
Conclusion: it is considered that Gamisogunjung-tang has an influence on control aging by activation the antioxidative enzyme systems in erythrocytes and decreasing the concentration of lipid in blood plasma.
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KEYWORD
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Gamisogunjung-tang, aging, anti-oxidation, thiobarbituric acid reactive substance(TBARS), superoxide dismutase(SOD)
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